In light of the past year, sponsors and CROs must focus now, more than ever, on building patient engagement into their study builds from the ground up. This involves applying the patients’ perspective into recruitment and outreach strategies, removing barriers for entry and retention, and creating healthy two-way information exchanges between patients and their clinical teams. But effective, sustainable patient engagement goes beyond single-focused solutions for recruitment and retention. This white paper focuses on how sponsors and CROs can put themselves into the mindsets of their patients and find strategic ways to incorporate patient engagement into the entire trial lifecycle.