The current clinical research enterprise is slow, siloed, inefficient and costly. Translating research into practice is similarly slow and inefficient. Aggregated, standardized, person-centric electronic health record (EHR) data is now available to help provide the needed research-ready data to help power clinical research. A novel, nationwide Cerner Learning Health Network 5M (LHN) has launched that leverages the EHR and a cloud-based data platform to power clinical research across a collaboration of heterogenous health systems.